ICAM1 and cerebral malaria: While this may seem at variance with the well-documented relationship between expression of group A PfEMP1 and severe malaria, it should be noted that the subset of group A dual-receptor-binding PfEMP1 containing ICAM-1-binding DBLβ domains has been associated specifically with cerebral malaria and not severe malaria in general (18), and that only 2 of the 124 children studied fulfilled the criteria for such a diagnosis.