KCNK18 and migraine disorder: First, we investigated whether loss of TRESK affects the excitability of small IB4− TG neurons, as the majority of these neurons express CGRP, the neuropeptide that plays an important role in migraine pathophysiology (Price and Flores, 2007; Tao et al., 2012; Edvinsson and Goadsby, 2019).