KCNK18 and migraine disorder: Although TRESK mRNA is highly expressed in human TG neurons and TRESK mutations are identified in migraine patients (Lafrenière et al., 2010; Andres-Enguix et al., 2012; Rainero et al., 2014; Flegel et al., 2015; LaPaglia et al., 2018), the causal relationship between TRESK function and migraine susceptibility is not established.