MSH2 and Lynch syndrome: Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant genetic syndrome that predisposes individuals to multiple cancer types and is caused by germline mutations in one of the mismatch repair genes, usually MLH1 (human MutL homolog 1), MSH2 (MutS protein homolog 2), MSH6 (MutS protein homolog 6), or PMS2 (PMS protein homolog 2) [1].