Immunotherapy with immune checkpoint inhibitors targeting cytotoxic T lymphocyte associated 4 (CTLA-4) or programmed cell death 1 (PD-1) or its ligand (PD-L1) can provide important clinical benefit to patients affected by multiple cancers, most notably lung cancer [1, 2], melanoma [3], renal cancer [4] and urothelial carcinoma [5]. This evidence concerns the gene CD274 and melanoma.