Moreover, a substantial minority of the subcommittee also agreed that significant burden and pace of disease requiring rapid tumor burden reduction (44%) and steroid dosing for any reason over 10 mg/day of prednisone or equivalent (38%) would be reasons not to give anti-PD-1 monotherapy to a platinum chemotherapy-refractory HNSCC patient. Here, PDCD1 is linked to head and neck squamous cell carcinoma.