CD274 and head and neck squamous cell carcinoma: Additionally, JAVELIN head and neck 100 (NCT02952586), an ongoing phase 3 trial assessing avelumab in combination with CRT for first-line treatment of locally advanced HNSCC, will determine if CRT plus PD-L1 blockade produces synergistic, superior anti-tumor effects compared to SOC CRT in prolonging PFS [157, 164].