Moreover, data from R/M HNSCC patients treated in four French centers (Antoine Lacassagne Center, Nice; Léon Bérard Center, Lyon; Curie Institute, Paris; Gustave Roussy, Villejuif) between September 2012 and September 2015 were retrospectively collected to investigate tumor growth kinetics post-treatment with PD-1/PD-L1 inhibitors. This evidence concerns the gene CD274 and neoplasm.