TP53 and acute myeloid leukemia: High throughput mRNA-sequencing analysis demonstrated that HHT upregulates the Notch and NF-κB pathway, as well as P53 family members (Additional file 7: Figure S7), suggesting the subsequent inhibition of proliferation in AML cells, at least partly, followed by P53 upregulation and BCL-2 downregulation [9, 12].