Our present data in TNBC cell lines, showing nucleolar emptying upon Pt-salts treatment but having different kinetics between HCC70 and HCC1937 cell lines, allow to conclude that APE1 and NPM1 proteins re-localization from nucleoli to nucleoplasm after treatment with Pt-compounds is a general phenomenon of cancer cells, even though with different kinetics. The gene discussed is NPM1; the disease is cancer.