NPM1 and cancer: Specifically, by using different cancer cell lines and specific NPM1- or APE1- gene knockout cell models, we explored: i) the protective role of APE1 and NPM1 in CDDP cytotoxicity and ii) whether the APE1 and NPM1 proteins were modulated in terms of level and subcellular localization upon Pt-compounds treatment in TNBC cancer cells.