TP53 and breast carcinoma: We demonstrated that PEITC treatment induces the restoration of p53R175H mutant in SK-BR-3 breast cancer cells and the restored p53R175H mutant is sensitive to degradation by proteasome degradation and autophagy pathways [15]. Therefore, to assess the effects of PEITC on p53 mutant protein levels in prostate cancer cells, p53R175H LAPC-4 and p53R248W VCaP cells were treated with PEITC for 4 h.