Given the diversity of human cancers with p53 mutations, types of p53 mutants (structural and contact) [16] and the pivotal role of p53 in cancer development, our findings raise important questions whether reactivation of mutant p53 by PEITC applies to other types of cancer cells expressing p53R175H mutant or cells harboring different p53 mutants. The gene discussed is TP53; the disease is cancer.