Recent studies on comprehensive characterization of the prostate cancer transcriptome and genome have revealed that p53 gene represents one of the most frequently mutated driver gene in primary prostate cancer [51] and mutations in p53 gene also occur at remarkably high frequency in metastatic tumors and metastatic castration-resistant prostate cancer (mCRPC) [52–54]. Here, TP53 is linked to Familial prostate cancer.