CFTR and cystic fibrosis: Rationale for working with CF cell models stems from the fact that the gene responsible for this disease – the cystic fibrosis transmembrane conductance regulator (CFTR) – encodes an abundance of well-classified SNVs (https://cftr2.org/) and synonymous nucleotide polymorphisms (SNPs, defined as SNVs with prevalence higher than 1% in the population [30]).