PCSK9 and coronary artery disorder: In the latest published guideline by the American Heart Association, alternative non-statin therapies, such as ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, should be considered in a ‘very high-risk’ subgroup of CAD patients, defined by the presence of multiple prior cardiovascular events, who have suboptimal LDL-C lowering despite maximally tolerated statin therapy [5].