Other kinases, such as ribokinase, D-glucose-6-phosphate dehydrogenase (G6PD) and ribose phosphate pyrophosphokinase (PRPP), which also play roles in regulating D-ribose metabolism, did not show significant changes in expression or activity level in T1DM rats compared to control rats. The gene discussed is G6PD; the disease is type 1 diabetes mellitus.