MAPT and type 1 diabetes mellitus: As shown, Tau was remarkably hyperphosphorylated at Ser396, AT8 (Ser199 and Ser202), while nonphosphorylated Tau (recognized by anti-Tau-1 antibody) was decreased in both the cortex (Supplementary Figure 6A, a’) and hippocampus (Supplementary Figure 6B, b’) in T1DM rats.