In another study, it has been shown that serum fetuin-B concentrations were significantly higher in patients with T2DM compared to patients with normal glucose tolerance test and prediabetes and positively correlated with plasma glucose in the fasting state and 2 h after meal, fasting insulin, HOMA-IR, first-phase glucose-stimulated insulin and TG (24). This evidence concerns the gene INS and type 2 diabetes mellitus.