We found a positive relationship between serum fetuin-B concentration and baseline serum insulin concentration (r = 0.36, P = 0.007), HOMA-IR (r = 0.31, P = 0.01) and HOMA-β (r = 0.43, P = 0.01), only in PCOS women. This evidence concerns the gene FETUB and polycystic ovary syndrome.