To evaluate the roles of CCR2 and CCL2 in STm-induced colitis, WT, Ccr2-deficient (Ccr2-/-), and Ccl2-deficient (Ccl2-/-) mice in the C57BL/6J strain background were treated with Sm prior to intragastric inoculation with PBS or STm. This evidence concerns the gene CCL2 and colitis.