Infection with LCMV clone 13 did not reveal any difference in the size of the LCMV-specific CD8+ T cells at the peak of the response, similar to our preliminary evidence from OVA/Montanide vaccination studies investigating the expansion of high-affinity CD4+ OT-2 and CD8+ OT-1 T cells at various time points. The gene discussed is CD8A; the disease is infection.