IL3 and cryoglobulinemia: And the authors believed IL-3 secreted either by the neoplastic cells at a level below detection by immunohistochemistry or by other cells in response to the presence of plasma cell myeloma may have played a role in causing the eosinophilia.[10] It may probably explain the increase of absolute eosinophil count in the case of MGUS-related cryoglobulinemia.