CD40LG and cryoglobulinemia: In 94 cases Mayo Clinic reported, thirty-nine patients (38%) had underlying MGUS, of which 25 (64%) were IgG, 12 (31%) were IgM and 2 (5%) patients had biclonal IgG and IgM MGUS.[2] Also, many other case reports showed Type I monoclonal cryoglobulinemia with IgG-Kappa, the same as our patient.[5,7,14–17]