IDO1 and Epstein-Barr virus infection: Rodriguez-Zas reported an association between indoleamine-pyrrole 2,3 dioxygenase 1 (IDO1) deficiency and phagocytosis and, additionally, immune challenges such as Bacille Calmette-Guerin activation of neurotoxic metabolite microglia phagocytic pathways might induce neurodegeneration and depression-like behavior.[28] Our results showed there were 2 hub genes (PSMD2 and PSMD6) associated with Epstein-Barr virus infection.