One study showed the putative role of proteasome PSMA7, PSMD9 (one of the hub genes in our study) and PSMD13 genes in susceptibility to antidepressive responses.[33] In addition, Minelli[33] found a positive correlation between PSMD9 rs1043307 and anxiety disorder in MDD comorbidities, although this result was not significant after adjusting for multiple comparisons. This evidence concerns the gene PSMD13 and anxiety disorder.