One study showed the putative role of proteasome PSMA7, PSMD9 (one of the hub genes in our study) and PSMD13 genes in susceptibility to antidepressive responses.[33] In addition, Minelli[33] found a positive correlation between PSMD9 rs1043307 and anxiety disorder in MDD comorbidities, although this result was not significant after adjusting for multiple comparisons. Here, PSMD9 is linked to major depressive disorder.