HE4 is a secreted, glycosylated protein that is overexpressed by serous and endometrioid EOCs and is part of the WFDC (previously WAP) family of proteins.[1] HE4 has been suggested as a complement or even as a better alternative to carbohydrate antigen 125 (CA125)[2–4], which was previously being used as a standard diagnostic biomarker and post treatment monitoring tool in ovarian cancer. This evidence concerns the gene WFDC2 and ovarian cancer.