LMNA and Hutchinson-Gilford progeria syndrome: Hutchinson–Gilford progeria syndrome (HGPS), the most well‐studied progeroid syndrome, is typically caused by a silent point mutation (1824C > T) that activates a cryptic splicing site within exon 11 of the LMNA gene, resulting in the synthesis of a prelamin A mRNA that contains an internal deletion of 150 base pairs.