Our previous analyses demonstrated that the gene expression level of GR, analyzed by real‐time RT‐PCR of exons 8 and 9a of GR (NR3C1) gene (specific for GRα and GRγ isoforms), shows significant correlation with IC50 of Pred in 72 BCP‐ALL cell lines.37 Of note, GR gene expression level in t(17;19)‐ALL cell lines was almost similar to that in t(1;19)‐ALL cell lines (data not shown), suggesting that some mechanism(s) besides the GR gene expression level may be associated with resistance to Pred in t(17;19)‐ALL cell lines. This evidence concerns the gene TLE5 and acute lymphoblastic leukemia.