Recently, P‐gp expression has been reported to be associated with resistance to glucocorticoids in inflammatory bowel disease.38 However, an association of higher P‐gp expression with resistance to glucocorticoids is unlikely at least in HALO1 cells, since knockout of P‐gp expression by CRISPR‐Cas9 did not overcome Dex resistance. Here, PGP is linked to inflammatory bowel disease.