miR‐338‐3p was reported to function as a tumour suppressor to inhibit renal cell carcinoma progression.34 miR‐338‐3p suppressed growth and invasion of non‐small cell lung cancer cells by targeting IRSA2. 35 Besides, miR‐338‐3p inhibited TC progression through targeting AKT3. 30 Our findings revealed that miR‐338‐3p suppressed cell proliferation and migration, whereas enhanced cell apoptosis in TC by targeting CCND1, which is similar with the roles of miR‐338‐3p/CCND1 axis in HCC.36 This evidence concerns the gene AKT3 and renal cell carcinoma.