The results revealed that mRNA expression levels of ALP, collagen type α I (Collagen‐1), bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 4 (BMP4), runt‐related transcription factor (Runx2), osterix (Sp7), osteocalcin (OCN) and osteopontin (OPN) in BMSCs were all up‐regulated in the presence of OM (Figure 1C). The gene discussed is RUNX2; the disease is ocular melanoma.