BMPR2 and pulmonary arterial hypertension: For example pulmonary arterialhypertension (PAH), which is between 6 and 15 cases per million adults13, 14 and adding ~1000 patients each year in the United Statesalone15 includes heritableform of PH where mutations in the bone morphogenetic protein receptor type 2(BMPR2) gene is one of the well know candidate.