REN and hypertensive disorder: Hypertension is a major risk factor for developing cardiovascular disease, which is estimated to result in 23.3 million deaths in 2030.1 The renin-angiotensin system (RAS) is an important pathway for the regulation of blood pressure and other cardiovascular processes.2 RAS is also associated with hypertension in spontaneously hypertensive rats (SHR),3 which is widely used in studying the antihypertensive effects and mechanisms of exogenous compounds.