For instance, intake of a pea protein hydrolysate (0.5% and 1% of diet) for 8 weeks inhibited renal renin mRNA by about 50% in Han:SPRD-cy rats, a chronic kidney disease model with hypertension.14 Similarly, egg protein-derived peptide, RVPSL, also decreased kidney renin mRNA expression after 4 weeks of daily intake.16 On the contrary, whey protein-derived dipeptide, IW, increased renin mRNA expression in the kidney.27 This discrepancy could be due to the difference in peptide structure and SHR tissues, in addition to other unknown factors. Here, REN is linked to hypertensive disorder.