Interestingly, the ACE2-Ang1-7-Mas axis also significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-κB signaling pathway.32 However, although Ang II mRNA expression was inhibited significantly by the three peptides, only LY decreased Ang II protein level in the myocardium when compared to the SHR that received only saline. The gene discussed is ACE2; the disease is pancreatitis.