CLPP siRNA reduced the expression of CLPP protein (HG+siCLPP and HF+siCLPP groups compared with HG+NC and HF+NC groups showed a decrease of 38% and 50%, respectively) (p < 0.05) (Figs. 3A,  3B) (raw data is available as Dataset 6). Here, CLPP is linked to hydrops fetalis.