Specifically, FOXO3 rs2802292 G-allele has been shown to have protective effects on several age-related diseases, as it has been associated with lower prevalence of coronary artery disease and cancer, fewer bone fractures, lower cardiovascular disease incidence, and better self-rated health, which strongly predicts mortality [[35], [36], [37],70]. Here, FOXO3 is linked to coronary artery disorder.