IRAK1 and cancer: Another tegument protein known as pUL48, is an HCMV encoded deubiquitinase enzyme (HCMV-DUB) that inhibits synthesis of I-IFNs, an anti-cancer factor, by deubiquitinating several signaling molecules such as TNF receptor-associated factor (TRAF)-6 and -3, interleukin-1 receptor-associated kinase-1 (IRAK1), interferon regulatory factor (IRF)-7 or stimulator of interferon genes (STING), that play a key role in anti-viral innate immunity [48].