The insulin resistance is associated with down-regulation of GLUT-4 expression in several cells, including cardiomyocytes, resulting in a reduction in glucose utilization as an energy substrate for the cardiac muscle due to a decrease in glycolysis rate and glucose oxidation, with a consequent increase in the use of FFA as an energetic source in the myocardium [22]. The gene discussed is SLC2A4; the disease is Insulin resistance.