The efficacy data of glargine U100 versus NPH was based on the results reported in the Lantus evaluation in Asian diabetics (LEAD) study [7], a 24-week randomised controlled study comparing these two insulins on glucose lowering and rates of hypoglycaemia in insulin-naïve Asian subjects with type 2 diabetes inadequately controlled on sulphonylurea. This evidence concerns the gene INS and type 2 diabetes mellitus.