Premature aging in Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a truncated prelamin A protein named “progerin,” which is produced via aberrant splicing resulting from a de novo synonymous c.1824C > T (p.G608G) point mutation in the LMNA gene (encoding lamin A and C) (De Sandre-Giovannoli et al., 2003, Eriksson et al., 2003). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.