ASGR1 and hepatocellular carcinoma: Compared to well-differentiated lines such as HepG2 and Hep3B, ASGR1/2 mRNA levels appeared to be much lower in poorly differentiated HCC lines characterized by their reduced expression of hepatocyte nuclear factor 4α (HNF4α) and E-Cadherin, markers for hepatocyte differentiation (Figure 1).