The observation that BRRM was associated with lower breast cancer-specific mortality for BRCA1 mutation carriers, and not for BRCA2 mutation carriers underscores that counseling for BRCA1 and BRCA2 mutation carriers regarding the choice between risk-reducing mastectomy and surveillance might be tailored, although confirmation in a larger cohort of especially BRCA2 mutation carriers is warranted. The gene discussed is BRCA1; the disease is breast cancer.