Besides, the ANXA2 mRNA and the ANXA2 Pseudogene ANXA2P2 may have direct or indirect interaction to promote tumor cell invasion through remodeling the hepatocellular carcinoma (HCC) cells movement that could be a novel predictive biomarker for the HCC patients risk evaluation of its recurrence or metastasis [74]. This evidence concerns the gene ANXA2 and neoplasm.