In addition, CKD rats with a higher severity of VC exhibited attenuated aortic miR‐125b expression compared to non‐CKD animals or those with less severe VC.70 Further, we have demonstrated that miR‐125b overexpression suppressed osteoblast markers including RUNX2 and osteocalcin in VSMCs. Here, RUNX2 is linked to chronic kidney disease.