ERBB2 and atherosclerosis: Similarly, Zhou et al57 showed that in heat‐injured human umbilical vascular ECs (HUVECs), miR‐125b up‐regulation was associated with decreased expression of human epidermal receptor 2 (HER2) and VEGF; neo‐angiogenesis and vascularization have been shown to play a vital role in plaque growth and destabilization, and anti‐angiogenetic therapies have been shown to ameliorate the progression of atherosclerosis.88 In in vitro atherosclerosis models, such as ox‐LDL‐treated HUVECs, miR‐125b was found to be suppressed over time, accompanied by the up‐regulation of podocalyxin.