Depending on whether the exons are involved in transcription and alternative splicing, CD44 is divided into a standard form (CD44s) and splice variant isoforms of the protein (CD44v).7 Several reports have documented that altered CD44 expression and the interaction of hyaluronan and CD44 may regulate cell growth, survival, invasion, and metastasis in various cancers.8, 9, 10. Here, CD44 is linked to cancer.