By comparing regulators that were identified for lean, obese, and merged islet expression data, Cck, C1ql3, Serpina7, Creld2, Svop, Smoc1, Tgfβ3, and Serpini1 were identified to affect islet function in obesity (Table 4). This evidence concerns the gene CRELD2 and obesity due to melanocortin 4 receptor deficiency.