By comparing regulators that were identified for lean, obese, and merged islet expression data, Cck, C1ql3, Serpina7, Creld2, Svop, Smoc1, Tgfβ3, and Serpini1 were identified to affect islet function in obesity (Table 4). The gene discussed is TGFB3; the disease is obesity due to melanocortin 4 receptor deficiency.