By comparing regulators that were identified for lean, obese, and merged islet expression data, Cck, C1ql3, Serpina7, Creld2, Svop, Smoc1, Tgfβ3, and Serpini1 were identified to affect islet function in obesity (Table 4). Here, SERPINA7 is linked to obesity due to melanocortin 4 receptor deficiency.