Dimethyl fumarate (DMF; Tecfidera®) is a oral disease modulating treatment (DMT) and the most prescribed drug for RRMS in the U.S. It’s suggested to act by activating the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2)4,5, which is a transcript of the NFE2L2 gene. This evidence concerns the gene NFE2L2 and mouth disorder.