GRIA2 and developmental and epileptic encephalopathy: The genetic and functional expression data presented here identify de-novo mutations and microdeletions involving GRIA2 as a cause of NDDs and DEE and underline the importance of the GluA2 subunit in the regulation of Ca2+ permeation and voltage rectification of AMPARs and therefore in human synaptic plasticity and brain development and function22,23,28.