We show that allergic asthma and elevated biomarkers of allergic disease, such as fractional exhaled nitric oxide (FeNO) and IgE, are associated with multiple differentially methylated CpGs and regions of genes that may alter the structure and function of epithelial cells and genes implicated in allergic asthma, Th2 activation, and eosinophilia. This evidence concerns the gene IGHE and Increased total eosinophil count.