In contrast to the cord blood analyses, many of the genes cross-sectionally associated with IgE in whole blood analyses from mid-childhood (ACOT7, ZFPM1, IL4, IL5RA, EPX, and PRG2)8 consistently had lower nasal DNAm among DMRs found for FeNO, total IgE (EPX), environment IgE (ACOT7), and allergic asthma (EPX). Here, IGHE is linked to allergic asthma.