BAP1 and cholangiocarcinoma: In that regard, engineered BAP1 mutations in healthy liver organoids have recently enabled the identification of the role of the epigenetic modifier BAP1 in CC.109 In this study, BAP1, a predicted histone deubiquitinase, was found to control epithelial integrity through the regulation of chromatin accessibility, which results in an acquisition of malignant features in organoids already harbouring other CC mutations.109 Similarly, postnatal tissue-derived intestinal organoids have been shown to retain the epigenetic landscape (methylome) of the tissue of origin.110