Multiple logistic regression analyses demonstrated that age [odds ratio (OR) = 1.044, 95% confidence interval (CI) = 1.013–1.076; P = 0.006], lymph node metastasis [OR = 0.094, 95% CI = 0.034–0.264; P < 0.001], and 131I radiotherapy [OR = 7.628, 95% CI = 2.721–21.378; P < 0.001] were significantly different between patients with or without BRAF V600E mutation (Table 4). The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.