Here, we have revealed a TRAPs-mediated regulatory mechanism of CD4+ T cells differentiation whereby HSP90α on the surface of TRAPs educate CD4+ T cells via a TLR2–autocrine IL-6 cascade to express IL-10 and IL-21 and engender immune suppression to promote tumor growth and metastasis (Fig. 7r). This evidence concerns the gene HSP90AA1 and neoplasm.