EPHA4 and amyotrophic lateral sclerosis: Although the role of EphA4 ligands in ALS is unknown, an EphA4 agonist that impedes EphA4 binding to its ligands, and an EphA4-Fc recombinant protein that reduces binding of EphA4 ligands to the receptor beneficially affected the phenotypes in mouse models for ALS [44, 47].