Animal studies had previously indicated that BETi affect plaque parameters; JQ1 attenuated angiotensin II-induced abdominal aortic aneurysm in ApoE (−/−) mice [59], and apabetalone reduced atherosclerosis in hyperlipidemic ApoE-deficient mice [23]. The gene discussed is APOE; the disease is abdominal aortic aneurysm.