CD274 and neoplasm: According to previous classification method [33], we categorized the classification of tumor immune microenvironment (TIME) into four types based on PD-L1 expression and CD8+ TIL density (type I, PD-L1+CD8+ TIL+; type II, PD-L1−CD8+ TIL−; type III, PD-L1+CD8+ TIL−; type IV, PD-L1−CD8+ TIL+).