Seven of 12 P450 mRNAs analysed by MANOVA (Cyp 1a2, 2c29, 2e1, 3a25, 4a10, 4a14 and 7a1) were significantly downregulated during infection as was flavin containing monooxygenase 3 (Fmo3) (Fig. 2). The gene discussed is FMO3; the disease is infection.