However, another Lxr target gene, Abcg1 [45] was upregulated more than fivefold, whilst transcription of both Srbp1c [31] and Abca1 [46] were comparatively unaffected by infection, suggesting that there may be redundancy in the Lxr pathway involved in regulation of these genes during Plasmodium infection. This evidence concerns the gene ABCG1 and infection.