Furthermore, with the increased treated concentrations of Ls, there showed a less or not significant changes in the protein expression of STAT3 and JAK2, while the protein expression levels of pSTAT3 and pJAK2 were gradually decreased, which reflected that Ls could inhibit the activation of pSTAT3 and pJAK2 in colorectal cancer cells. The gene discussed is JAK2; the disease is colorectal cancer.