In a transwell cell invasion assay, tumor cells with SREBP1 expression (HT29 SREBP1oe, 44.83 ± 1.58, and SW620, 31.67 ± 0.88) were significantly more invasive than those cells that express lower levels of SREBP1 (HT29, 18.33 ± 0.88, and SW620 SREBP1kd, 9.83 ± 0.95) (both P < 0.001) (Fig. 2a, b, c). The gene discussed is SREBF1; the disease is neoplasm.