In previous studies, we investigated the roles of MMPs including MMP2, MMP7, MMP8, MMP9 and MMP13 in the mice colorectal cancer model tissue, and observed that MMP7, MMP8, MMP9 are more important in colorectal cancer invasion and migration, and that MMP7 is regulated by NF-κB pathway. The gene discussed is NFKB1; the disease is colorectal cancer.