Indeed, depletion of these antioxidants is often associated with chronic inflammation and other diseases (Bonham et al., 1999; Ruan et al., 1997; Huijskens et al., 2016; Rose et al., 2012) and antioxidant therapy such as high-dose intravenous vitamin C treatment leads to decrease of inflammation markers such as CRP (Mikirova et al., 2012; Carr and Cook, 2018; Block et al., 2009). The gene discussed is CRP; the disease is inflammatory response.