In conclusion, the aforementioned findings provided evidence that miR‐539 could result in the suppression of cell migration, invasion, migration and EMT in PCa by inactivating the TGF‐β/Smad4 signalling pathway through the direct down‐regulation of DLX1 (Figure 11), which provides new insights for future study of PCa treatment. This evidence concerns the gene DLX1 and posterior cortical atrophy.