Compared with the blank and NC groups, the PCa cell invasion in the miR‐539 mimic and siRNA‐DLX1 groups was evidently reduced, while the miR‐539 inhibitor group showed the opposite trend (P < 0.05) and the miR‐539 inhibitor + si‐DLX1 group presented with no obvious difference (P > 0.05). Here, DLX1 is linked to posterior cortical atrophy.