FAT4 and colorectal cancer: Multiple studies had indicated that PI3K/AKT signaling was involved in regulating the proliferation, apoptosis and metastasis of GC or other tumors by inducing EMT.31, 32 Wei et al33 indicated that FAT4 could promote autophagy and inhibit the EMT of colorectal cancer, by regulating the PI3K/AKT/mTOR and PI3K/AKT/GSK‐3β signaling pathway.