EMT is an vital mechanism of tumor cell invasion and metastasis, with the declining of E‐cadherin and increasing of N‐cadherin, vimentin in its process.30 In this study, E‐cadherin was increased and N‐cadherin and vimentin was reduced after down‐regulating miR‐107 or up‐regulating FAT4, demonstrating that miR‐107 and FAT4 may affect the migration and invasion of GC cells by regulating EMT, which was consistent with this study. This evidence concerns the gene FAT4 and gastric cancer.